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Index > Protein center > Mme(Gene name) > Mouse
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  • Mme (Gene name),
  • Neprilysin (Protein name ),  NEP_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Mme;
    Protein name:
    Neprilysin;
    Alternative:
    Enkephalinase;Atriopeptidase;Skin fibroblast elastase(SFE);Neutral endopeptidase 24.11(NEP;Neutral endopeptidase);
    CD:
    CD10;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (By similarity). Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
    Subcellular Location:
    Cell membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    750
    Sequence:
    50:
    MGRSESQMDI | TDINAPKPKK | KQRWTPLEIS | LSVLVLLLTI | IAVTMIALYA | 
    100:
    TYDDGICKSS | DCIKSAARLI | QNMDASVEPC | TDFFKYACGG | WLKRNVIPET | 
    150:
    SSRYSNFDIL | RDELEVILKD | VLQEPKTEDI | VAVQKAKTLY | RSCINESAID | 
    200:
    SRGGQPLLKL | LPDIYGWPVA | SDNWDQTYGT | SWTAEKSIAQ | LNSKYGKKVL | 
    250:
    INFFVGTDDK | NSTQHIIHFD | QPRLGLPSRD | YYECTGIYKE | ACTAYVDFMI | 
    300:
    SVARLIRQEQ | SLPIDENQLS | LEMNKVMELE | KEIANATTKP | EDRNDPMLLY | 
    350:
    NKMTLAKLQN | NFSLEVNGKS | FSWSNFTNEI | MSTVNINIQN | EEEVVVYAPE | 
    400:
    YLTKLKPILT | KYSPRDLQNL | MSWRFIMDLV | SSLSRNYKES | RNAFRKALYG | 
    450:
    TTSETATWRR | CANYVNGNME | NAVGRLYVEA | AFAGESKHVV | EDLIAQIREV | 
    500:
    FIQTLDDLTW | MDAETKKKAE | EKALAIKERI | GYPDDIISNE | NKLNNEYLEL | 
    550:
    NYREDEYFEN | IIQNLKFSQS | KQLKKLREKV | DKDEWISGAA | VVNAFYSSGR | 
    600:
    NQIVFPAGIL | QPPFFSAQQS | NSLNYGGIGM | VIGHEITHGF | DDNGRNFNKD | 
    650:
    GDLVDWWTQQ | SANNFKDQSQ | CMVYQYGNFS | WDLAGGQHLN | GINTLGENIA | 
    700:
    DNGGIGQAYR | AYQNYVKKNG | EEKLLPGLDL | NHKQLFFLNF | AQVWCGTYRP | 
    750:
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    String:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Neprilysin
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    E1785h
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    96T
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    ELISA Kit for Mouse Neprilysin
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    E1785r
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    MSDS:
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    96T
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    ELISA Kit for Mouse Neprilysin
    MSDS:
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    ELISA Kit for Mouse Neprilysin
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    ELISA Kit for Mouse Neprilysin
    Cat.:
    E1785m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Neprilysin
    Cat.:
    U1785m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Neprilysin
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Neprilysin
    Cat.:
    U1785r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Neprilysin
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Neprilysin
    Cat.:
    U1785h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse Neprilysin
    Cat.:
    P1785Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Neprilysin
    Cat.:
    P1785Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Neprilysin
    Polyclonal Antibody for Mouse Neprilysin
    Cat.:
    P1785Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Neprilysin
    Monoclonal Antibody for Mouse Neprilysin
    Monoclonal Antibody for Mouse Neprilysin
    Monoclonal Antibody for Mouse Neprilysin
    Monoclonal Antibody for Mouse Neprilysin
    Monoclonal Antibody for Mouse Neprilysin
    Protein for Mouse Neprilysin
    Protein for Mouse Neprilysin
    Protein for Mouse Neprilysin
    Protein for Mouse Neprilysin
    Protein for Mouse Neprilysin

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    Precision
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    Linearity
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    References
    1. 1.
      "Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site."
      Chen C.Y. , Salles G. , Seldin M.F. , Kister A.E. , Reinher E.L. , Shipp M.A.
      J. Immunol.148:2817-2825(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Epididymis.
      tissue: Testis.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: FVB/N.
      tissue: Embryonic germ cell.
      tissue: Mammary tumor.
    4. 4.
      Lubec G. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 473-479;IDENTIFICATION BY MASS SPECTROMETRY
      strain: OF1.
      tissue: Hippocampus.
    5. 5.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145; ASN-285; ASN-311 AND ASN-317
    6. 6.
      "Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses."
      Morisaki N. , Moriwaki S. , Sugiyama-Nakagiri Y. , Haketa K. , Takema Y. , Imokawa G.
      J. Biol. Chem.285:39819-39827(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS SKIN FIBROBLAST ELASTASE;FUNCTION
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